B3 Confusion: Niacin, Nicotinamide, Niacinamide, NAD, and NMN What’s the Difference? (2023)

If you are interested in longevity science, you’ve probably seen a lot of chatter about NAD, NMN, niacin, nicotinamide, and niacinamide… and it’s possible you are also confused. We’ll do our best to break this down and simplify all of this for you.

Niacin is Vitamin B3

B3 Confusion: Niacin, Nicotinamide, Niacinamide, NAD, and NMN What’s the Difference? (1)

Niacin is just another name for vitamin B3. You might also see it called nicotinic acid as well. Nicotinic acid is the scientific name for niacin. When you buy a B3 supplement, you are generally buying niacin (but check the label!).

Niacin is a micronutrient that’s important for helping regulate your metabolism and nervous system function. It also has antioxidant properties and our bodies need it to survive.

But, we can’t make niacin.

You can get niacin by eating plant based products such as:

Niacin is also good for helping cholesterol levels. It raises HDL (good cholesterol) and lowers LDL (bad cholesterol) levels. One downside is that it causes skin flushing and rashes in some people. It is generally harmless, but not everyone likes the effect.

Nicotinamide and Niacinamide are the Same Thing

B3 Confusion: Niacin, Nicotinamide, Niacinamide, NAD, and NMN What’s the Difference? (2)

Nicotinamide and niacinamide are the exact same thing. For the purposes of this post, we’ll just be saying niacinamide.

Niacinamide is also a form of vitamin B3, but it’s slightly different from niacin. Niacinamide is the vitamin B3 that you get from meat and poultry. In other words, it comes from animal based foods. Many grain products are also fortified with it.

Niacinamide helps keep your skin healthy and is a popular additive in skincare products. It’s often used to treat acne or rosacea. It doesn’t cause flushing like niacin does. All Qyral skincare products contain niacinamide.

Nicotinamide Mononucleotide (NMN)

B3 Confusion: Niacin, Nicotinamide, Niacinamide, NAD, and NMN What’s the Difference? (3)

NMN is produced in our bodies but there are bio-synthetic forms we can supplement with. The NMN molecule is small enough to be absorbed if taken orally. One early study shows that supplementing with NMN can increase muscle function in older men. Another shows it can increase insulin sensitivity in some older women.

NMN has gotten a lot of press over the past few years as it has been promoted by Harvard professor Dr. David Sinclair. His research shows that it has anti-aging properties because it helps our bodies produce NAD+.

NAD+ (Nicotinamide Adenine Dinucleotide) is the Stuff We Want

B3 Confusion: Niacin, Nicotinamide, Niacinamide, NAD, and NMN What’s the Difference? (4)

All of these forms of B3 have benefits, but NAD+ is what we ultimately want. Your cells need NAD to function. It’s a molecule that helps your body turn food into energy. You need that energy for moving and thinking, which slow down as you age. Healthy cells mean your body can more easily repair itself.

Studies show that NAD+ can:

  • Support healthy aging

  • Protect your cells from stress

  • Helps repair DNA

  • Helps your circadian rhythm (your sleep-wake cycle)

The bad news is that as we age, the amount of NAD+ in our cells decreases. But we just can’t pop an NAD pill and call it good. The molecule is big enter your cells and do its job.

You can take NMN, niacinamide, or even niacin, which are small enough to get into your cells, break down, and convert into NAD+ naturally. NMN seems to be the most efficient form of B3 for this purpose.

NAD+ is also required for sirtuins to do their thing. Sirtuins are proteins that help us live longer and can help us stay thin. Learn more about sirtuins in this blog post.

Research on the B3 Family is Evolving

B3 Confusion: Niacin, Nicotinamide, Niacinamide, NAD, and NMN What’s the Difference? (5)

Scientists are actively studying niacin, niacinamide (nicotinamide), NAM, and NAD+ to learn more about how they affect the aging process. At Qyral are staying up to date on the progress they are making in the hopes of bringing more benefits to you in the future.

All of Qyral’s skincare products and our supplements are formulated with niacinamide. Depending on your personalized skincare assessment, the products we recommend will be formulated with the right niacinamide for your skin type!

FAQs

Is niacin and NMN the same? ›

The terms “nicotinic acid,” “niacin,” and “vitamin B3” can be used interchangeably. The derivatives of nicotinic acid include niacinamide (also called nicotinamide), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN).

What is the difference between nicotinamide and NMN? ›

Nicotinamide riboside can enter cells directly.

NR and NMN are chemically identical, with the exception of one phosphate group present on NMN. The study demonstrates that this additional phosphate group must be removed from NMN, converting it into nicotinamide riboside before it can enter the cell.

Which is better niacinamide or nicotinamide? ›

Nicotinamide and niacinamide are the exact same thing. For the purposes of this post, we'll just be saying niacinamide. Niacinamide is also a form of vitamin B3, but it's slightly different from niacin. Niacinamide is the vitamin B3 that you get from meat and poultry.

What is difference between nicotinamide and niacinamide? ›

Nicotinamide, also known as niacinamide, is a water-soluble amide form of niacin or vitamin B3. It is found in foods such as fish, poultry, eggs, and cereal grains. It is also marketed as a dietary supplement, and as a non-flushing form of niacin.

Which is better NMN or niacin? ›

Niacin (also known as nicotinic acid) and nicotinamide (NAM, also known as niacinamide) are all different forms of vitamin B3. So NAM needs first to be converted into NMN which then builds NAD+. It's better to take NMN, which is a direct precursor to NAD+.

Is it better to take NMN or NAD? ›

NMN is more easily absorbed into the bloodstream. NAD+ may have a stronger effect on your brain and mental health. NMN may have a stronger effect on your physical health.

Is vitamin B3 the same as NAD? ›

The human body relies on nicotinamide adenine dinucleotide (NAD), the active coenzyme form of vitamin B3, for most of its essential functions. Among other benefits, NAD helps boost energy, improve mental clarity, and promote a youthful appearance.

Should I take NMN and NAD together? ›

Choosing to supplement with NMN along with NAD provides a much more direct path to promoting cell metabolism and is thus a much quicker means of doing the same. In addition, NMN has been found to improve insulin activity and production, resulting in additional metabolic benefits as well as glucose tolerance.

Is NAD and niacin the same? ›

Niacin is naturally present in many foods, added to some food products, and available as a dietary supplement. All tissues in the body convert absorbed niacin into its main metabolically active form, the coenzyme nicotinamide adenine dinucleotide (NAD).

What is the best form of vitamin B3? ›

In general, the body handles nicotinamide better than niacin since it is more similar to NAD, which results in greater bioavailability.

Is nicotinamide a NMN? ›

Nicotinamide mononucleotide (NMN) is one of the main precursors of nicotinamide adenine dinucleotide (NAD+) — an essential enzyme for various critical cell functions, including metabolism, DNA repair, cell growth and survival.

What are the side effects of vitamin B3 nicotinamide? ›

Side effects may include diarrhea, headache, stomach discomfort, and bloating. High doses (50 mg or more) of niacin can cause side effects. The most common side effect is called "niacin flush," which is a burning, tingling sensation in the face and chest, and red or flushed skin.

What is the difference between nicotinamide and NAD? ›

The key difference between nicotinamide adenine dinucleotide and nicotinamide riboside is that nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism that is found in all living cells, while nicotinamide riboside (niagen) is an alternative form of vitamin B3 that is functional as a precursor to ...

What are the benefits of vitamin B3 nicotinamide? ›

Niacinamide is one form of vitamin B3 (niacin) that plays an important role in energy metabolism and cell health. It may offer benefits related to skin care and skin cancer, as well as chronic kidney disease and type 1 diabetes. Niacinamide is generally considered safe with few side effects at appropriate doses.

What happens when you stop taking NMN? ›

Re: What happens when you stop taking NMN

Yes your body would just return to homeostasis and produce only what your body normally would at your age. NMN is more like a vitamin and not like a hormone as Testosterone is.

Which is more effective niacin or niacinamide? ›

In medical circles, niacinamide is known for being extremely effective when it comes to treating acne, redness, hyperpigmentation, and signs of aging — plus it's compatible with all skin types. Niacin, on the other hand, is more popularly known in the wellness world for supporting cardiovascular health.

Is it OK to take NMN everyday? ›

Is NMN safe, and does it have side effects? NMN is an ideal supplement to increase cellular levels of NAD because it's well-tolerated, and both human and animal studies have observed it had minimal side effects. Research in humans has shown that doses of up to 1,200 mg daily are safe to consume.

Will NMN make me look younger? ›

Does NMN make you look younger? As of 2022, there haven't been any studies to evaluate the effects of NMN on human skin. However, the supplement has shown very promising results in mice, improving metabolism, preventing diseases, and providing a general anti-ageing effect.

What are the risks of taking NMN? ›

Some NAD boosting supplements – when taken at high levels – have been reported to have side effects such as nausea, diarrhoea, flushing, stomach discomfort and indigestion. However, people involved in studies with NMN supplements have reported no significant side effects at dosages up to 1,200mg.

At what age should you take NMN? ›

Taking the human and animal studies of efficacy and safety into consideration and calculating optimal NMN doses, the recommended dose that adults between 30 and 60 years old take is 500 mg per day. People over age 65 can safely take 750 mg per day to maximize NMN's benefits.

What brand of NMN does David Sinclair take? ›

He is best known for his work on understanding why we age and how to slow its effects. Although Sinclair never recommends a particular NNM company, he does recommend GMP NMN.

How much niacin should I take to increase my NAD? ›

Niacin repletes NAD+ deficiency in human muscle and blood

The research team supplemented PEO patients and healthy matched controls with a slowly increasing dose of niacin, from 250 mg/day up to 750 or 1000 mg/day for four months. They continued the follow-up of the treatment effect up to 10 months in patients.

What does NMN mean? ›

NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. At the molecular level, it is a ribo-nucleotide, which is a basic structural unit of the nucleic acid RNA.

Which NMN brand is best? ›

Top 6 Best NMN Supplements In 2023
  • Peak Performance NMN + Resveratrol – Editor's Choice.
  • Wonderfeel YoungrTM NMN – Best Option.
  • OMRE NMN+ Resveratrol – Best Pure NMN.
  • Double Wood NMN – Best Third-Party Tested.
  • Quicksilver NAD+ Platinum – Best Liposomal NAD Booster.
  • ProHealth Longevity NMN Pro 300 – Fastest Absorption NMN.
6 days ago

Should I take NMN on an empty stomach? ›

Nicotinamide mononucleotide (NMN) is available in a pill and powder form, as well as a sublingual powder form. NMN should be taken 1 hour before breakfast on an empty stomach to maximize its absorption.

What is the best form to take NMN? ›

Some older reports or websites still claim the best way to take NMN is sublingually (melting it under the tongue), or to even inject it. This has been debunked by recent research, showing that NMN is very well absorbed when taken orally.

Can niacin make you look younger? ›

Niacin helps smooth wrinkles.

Niacin benefits your skin by stimulating production of collagen and elastin, which helps to smooth those pesky fine lines and wrinkles.

How much B3 should you take a day? ›

The Recommended Dietary Allowance (RDA) for adults 19+ years is 16 mg NE for men, 14 mg NE for women, 18 mg NE for pregnant women, and 17 mg NE for lactating women.

What is another name for niacin? ›

Niacin (also known as vitamin B3) is one of the water-soluble B vitamins. Niacin is the generic name for nicotinic acid (pyridine-3-carboxylic acid), nicotinamide (niacinamide or pyridine-3-carboxamide), and related derivatives, such as nicotinamide riboside [1-3].

What is a substitute for NMN? ›

Nicotinamide Riboside (NR) as an Alternative to Nicotinamide Mononucleotide (NMN) Nicotinamide mononucleotide (NMN) has been a popular dietary supplement due to its role in boosting NAD+ levels.

Is NAD+ the same as niacin? ›

Nicotinamide riboside, or niagen, is an alternative form of vitamin B3, also called niacin. Like other forms of vitamin B3, nicotinamide riboside is converted by your body into nicotinamide adenine dinucleotide (NAD+), a coenzyme or helper molecule.

What is the difference between niacin and NAD? ›

Niacin is an oxidated form of nicotine that the body can convert into NAD. Nicotinamide is an amide of niacin that is more similar to NAD and has fewer side effects. Nicotinamide riboside is a synthetic form of nicotinamide that has different attributes.

What are the benefits of B3 nicotinamide? ›

5 health benefits of niacin
  • Improves blood fat levels. Niacin may help to improve your blood fat levels by: ...
  • May reduce blood pressure. ...
  • May help treat type 1 diabetes. ...
  • Boosts brain function. ...
  • Improves skin health.

Are niacin and niacinamide the same? ›

Vitamin B3 is one of 8 B vitamins. It is also known as niacin (nicotinic acid) and has 2 other forms, niacinamide (nicotinamide) and inositol hexanicotinate, which have different effects from niacin. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which the body uses to produce energy.

Which form of NMN is best? ›

Top 6 Best NMN Supplements In 2023
  • Peak Performance NMN + Resveratrol – Editor's Choice.
  • Wonderfeel YoungrTM NMN – Best Option.
  • OMRE NMN+ Resveratrol – Best Pure NMN.
  • Double Wood NMN – Best Third-Party Tested.
  • Quicksilver NAD+ Platinum – Best Liposomal NAD Booster.
  • ProHealth Longevity NMN Pro 300 – Fastest Absorption NMN.
6 days ago

How do I choose the best NMN supplement? ›

How to Choose the Best NMN Supplement for You: What to Look For
  1. A Supplier with an Excellent Reputation. Quality NMN comes from quality suppliers. ...
  2. Good Manufacturing Facility Practices. ...
  3. Third-Party Testing. ...
  4. Product Purity. ...
  5. Pricing. ...
  6. Consumer-Satisfaction Guarantee. ...
  7. Product Research. ...
  8. Form of Delivery.
Feb 1, 2022

Is it worth it to take NMN? ›

NMN is an ideal supplement to increase cellular levels of NAD because it's well-tolerated, and both human and animal studies have observed it had minimal side effects. Research in humans has shown that doses of up to 1,200 mg daily are safe to consume.

What diseases are caused by NAD deficiency? ›

NAD deficiency is linked to disease through genetic and environmental means. Severe niacin deficiency causes pellagra, characterized by dermatitis, diarrhea, dementia, and death.

When should I take niacin morning or night? ›

In general, the immediate-release form of niacin should be taken after your evening meal and the extended-release form should be taken at bedtime after a low-fat snack. Taking it in the morning or on an empty stomach might cause you to experience more side effects such as flushing and stomach upset.

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