Amoxicillin vs Clindamycin Comparison - Drugs.com (2023)

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View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
AmoxicillinClindamycin
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View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
AmoxicillinClindamycin
Prescription only

Amoxicillin is a penicillin-type antibiotic that may be used to treat infections caused by susceptible bacteria. It is usually well tolerated. Prescribed for Bacterial Infection, Bacterial...View more

Prescription only

Clindamycin is an antibiotic that is usually reserved for treating anaerobic infections or other serious infections caused by gram-positive bacteria in penicillin-allergic people. The risk of C...View more

More aboutAmoxicillinMore aboutClindamycin
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Ratings & Reviews

Amoxicillin has an average rating of6.2 out of 10 from a total of351 ratings on Drugs.com.52% of reviewers reported a positive effect, while 32% reported a negative effect.

Clindamycin has an average rating of5.7 out of 10 from a total of781 ratings on Drugs.com.43% of reviewers reported a positive effect, while 35% reported a negative effect.

View all 351 reviews

View all 781 reviews

Drug Class
Side Effects

See also: amoxicillin side effects in more detail.

See also: clindamycin side effects in more detail.

Pricing and Coupons* Prices are without insurance
Quantity4 capsule
Dosage500 mg
Per Unit*$2.48
Cost*$9.93

View all amoxicillin prices

Quantity4 capsule
Dosage150 mg
Per Unit*$2.76
Cost*$11.02

View all clindamycin prices

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Oral capsule
  • Oral powder for reconstitution
  • Oral tablet
  • Oral tablet, chewable
  • Oral tablet, extended release
  • Injectable solution
  • Intravenous solution
  • Oral capsule
  • Oral powder for reconstitution
Brand Names
Amoxil, Apo-AmoxiCleocin, Cleocin HCl, Cleocin Pediatric, Cleocin Phosphate, Cleocin Phosphate ADD-Vantage
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

1.7 hours

3.4 hours

CSA Schedule **View glossary of terms

N

Not a controlled drug

Is not subject to the Controlled Substances Act.

N

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

B

Category BNo proven risk in humans

See the full pregnancy warnings document.

B

Category BNo proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 37 drugs are known to interact with amoxicillin:

  • 4 major drug interactions (18 brand and generic names)
  • 25 moderate drug interactions (209 brand and generic names)
  • 8 minor drug interactions (39 brand and generic names)

A total of 83 drugs are known to interact with clindamycin:

  • 3 major drug interactions (8 brand and generic names)
  • 78 moderate drug interactions (329 brand and generic names)
  • 2 minor drug interactions (7 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions
First Approval Date

January 18, 1974

February 22, 1970

WADA ClassView World Anti-Doping Agency classifications.

N/A

N/A

More Information
Patient resources
Professional Resources
Related Treatment Guide
(Video) Clindamycin | Bacterial Targets, Mechanism of Action, Adverse Effects

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

(Video) How and When to use Clindamycin? (Cleocin, Dalacin and Clinacin) - Doctor Explains

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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